Propofol Cardioprotection against Myocardial Ischemia-Reperfusion Injury: A Mechanistic Review

  • Xiaowen Mao Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Zhi-dong Ge Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Xiang Xie Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Qingquan Lian Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
  • Zhengyuan Xia Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Keywords: Antioxidant, Cardioprotection, Myocardial ischemia reperfusion injury, Nitric oxide, Propofol, Protective survivor activating factor enhancement pathway, Reperfusion injury signaling kinase pathway

Abstract

Reperfusion after prolonged ischemia is necessary to rescue injured hearts while it paradoxically worsens cardiac injury, a phenomenon termed myocardial ischemia-reperfusion injury (MIRI). Overproduction of reactive oxygen species, calcium overload, and inflammation contribute to the pathogenesis of MIRI. Propofol, a commonly used anesthetic with antioxidant property, has been shown to be cardioprotective in experimental studies and in some small clinical trials of cardiac surgery using cardiopulmonary bypass. However, its effectiveness of cardioprotection needs to be confirmed in large clinical trials, and the mechanisms of its action remain a focus of current research. The purpose of this review is to delineate and summarize the mechanism underlying propofol-mediated cardioprotection against MIRI.

Published
2016-05-01
How to Cite
Mao, X., Ge, Z.- dong, Xie, X., Lian, Q., & Xia, Z. (2016). Propofol Cardioprotection against Myocardial Ischemia-Reperfusion Injury: A Mechanistic Review. Reactive Oxygen Species, 1(3), 178‒188. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/34
Section
Review Articles