Oxygen and Oxygen Toxicity: The Birth of Concepts

  • Hong Zhu CUSOM, Campbell University, Buies Creek, NC 27506, USA
  • Kassim Traore CUSOM, Campbell University, Buies Creek, NC 27506, USA
  • Arben Santo EVCOM, Virginia Tech CRC, Blacksburg, VA 24060, USA
  • Michael A. Trush The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
  • Y. Robert Li CUSOM, Campbell University, Buies Creek, NC 27506, USA; Virginia Tech-Wake Forest University SBES, Blacksburg, VA 24061, USA
Keywords: Oxygen, Oxygen toxicity, Reactive oxygen species, Redox signaling


Molecular dioxygen (O2) is an essential element of aerobic life, yet incomplete reduction or excitation of O2 during aerobic metabolisms generates diverse oxygen-containing reactive species, commonly known as reactive oxygen species (ROS). On the one hand, ROS pose a serious threat to aerobic organisms via inducing oxidative damage to cellular constituents. On the other hand, these reactive species, when their generation is under homeostatic control, also play important physiological roles (e.g., constituting an important component of immunity and participating in redox signaling). This article defines oxygen and the key facts about oxygen, and discusses the relationship between oxygen and the emergence of early animals on Earth. The article then describes the discovery of oxygen by three historical figures and examines the birth of the concepts of oxygen toxicity and the underlying free radical mechanisms. The article ends with a brief introduction to the emerging field of ROS-mediated redox signaling and physiological responses.
How to Cite
Zhu, H., Traore, K., Santo, A., Trush, M. A., & Li, Y. R. (2016). Oxygen and Oxygen Toxicity: The Birth of Concepts. Reactive Oxygen Species, 1(1), 1–8. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/3
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