An Overview of SARS-CoV-2 (COVID-19) Infection: The Importance of Molecular Hydrogen as an Adjunctive Therapy

  • Grace Russell Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, England
  • Mubasher Rehman Department of Microbiology, Hazara University Mansehra, Pakistan
  • Tyler W. LeBaron Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Slovak Republic; Molecular Hydrogen Institute, Enoch, Utah, USA
  • David Veal Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, England
  • Emmanuel Adukwu Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, England
  • John T. Hancock Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, England
Keywords: COVID-19; Cytokine storm; Molecular hydrogen; Reactive oxygen species; SARS-CoV-2; Virus

Abstract

SARS-CoV-2 is an emerging β-coronavirus that causes COVID-19 disease, manifesting primarily as a pulmonary infection that can rapidly progress into severe and acute respiratory distress in susceptible patients. Initial reports of severe pulmonary infections first arose in December 2019 and were reported to the World Health Organization by the Wuhan Municipal Health Commission, China. Within months SARS-CoV-2 rapidly disseminated across the globe causing an unprecedented pandemic that has reached every inhabited continent and provoked an international response into research involving multiple disciplines to combat this novel contagion. Molecular hydrogen (H2) has shown potential as an emerging and effective therapy for numerous diseases, particularly those which involve excessive production of inflammatory agents as well as reactive oxygen/nitrogen species. Of pertinence to the investigations of SARS-CoV-2 infection are the increasing reports that suggest that H2 has therapeutic qualities in the treatment of chronic inflammatory lung conditions, and as such it is likely that this diatomic gas may alleviate the severe pulmonary symptoms of COVID-19. Here, the aim is to review the current research into SARS-CoV-2 and to better understand how treatment with molecular hydrogen is likely to affect cellular responses during SARS-CoV-2 infection.

Published
2020-07-01
How to Cite
Russell, G., Rehman, M., LeBaron, T. W., Veal, D., Adukwu, E., & Hancock, J. T. (2020). An Overview of SARS-CoV-2 (COVID-19) Infection: The Importance of Molecular Hydrogen as an Adjunctive Therapy. Reactive Oxygen Species, 10(28), 150–165. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/271
Section
Review Articles