5-Methoxyindole-2-Carboylic Acid (MICA) Fails to Retard Development and Progression of Type II Diabetes in ZSF1 Diabetic Rats

  • Chun-Yan Li Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA; Shantou University Medical College, Shantou515041, Guangdong, China
  • Wei-Xing Ma Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA; Qingdao University of Science and Technology, Qingdao266042, Shandong, China; Technical Center of Qingdao Customs, Qingdao266002, Shandong, China
  • Liang-Jun Yan Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
Keywords: Diabetes; Dihydrolipoamide dehydrogenase; 2-Methoxyindole-2carboylic acid;Mitochondria

Abstract

5-Methoxyindole-2-carboxylic acid (MICA) is a well-established reversible inhibitor of mitochondrial dihydrolipoamide dehydrogenase (DLDH). This chemical, as an indole derivative, has been shown to be neuroprotective against ischemic stroke injury when administered either before or after ischemic stroke in animal models. MICA has also been studied as a potential antidiabetic agent by numerous investigators, though the underlying mechanisms remain sketchy. To attempt to elucidate the mechanisms of its antidiabetic action, we tested the effect of MICA on ZSF1 rat, a widely used rodent model of type 2 diabetes. ZSF1 rats as well as its healthy controls were fed with control diet or MICA-containing diet (200 mg/kg/day) for 9 weeks. Unexpectedly, comparison of body weight changes and blood glucose levels at the end of the 9-week’s feeding period indicated that MICA failed to show any anti-diabetic effect in the ZSF1 diabetic rats. The reasons for this failure were discussed.

Published
2020-05-01
How to Cite
Li, C.-Y., Ma, W.-X., & Yan, L.-J. (2020). 5-Methoxyindole-2-Carboylic Acid (MICA) Fails to Retard Development and Progression of Type II Diabetes in ZSF1 Diabetic Rats. Reactive Oxygen Species, 9(27), 144–147. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/262
Section
Letters to the Editor