Oxidative Stress in the Pathogenesis of Corneal Endothelial Dystrophies and Other Corneal Diseases

  • Sanjukta Guha Brien Holden Eye Research Centre, LVPEI, Hyderabad, India; Manipal Academy of Higher Education, Manipal, India
  • Sunita Chaurasia Tej Kohli Cornea Institute, LVPEI, Hyderabad, India
  • Sanhita Roy Brien Holden Eye Research Centre, LVPEI, Hyderabad, India; Tej Kohli Cornea Institute, LVPEI, Hyderabad, India
Keywords: Congenital hereditary endothelial dystrophy; Corneal endothelial dystrophy; Nrf2; Oxidative stress; Reactive oxygen species; Keratoconus; Fuchs’ endothelial corneal dystrophy; Posterior polymorphous corneal dystrophy; Granular corneal dystrophy type 2; Schnyder corneal dystrophy

Abstract

Cornea being constantly exposed to sunlight and atmospheric oxygen is readily prone to oxidative damages. The functional antioxidant signaling helps maintain the levels of reactive oxygen species in the cells and keeps the cornea healthy. Corneal endothelial dystrophies include a group of corneal diseases that are marked by progressive degeneration of corneal endothelium leading to loss of vision. The increased level of oxidative stress in several corneal endothelial dystrophies indicates that there might be disruption in proper functioning of these signaling pathways. Various strategies to improve antioxidant signaling pathways may help develop novel clinical interventions to combat degeneration of endothelial cells that leads to vision loss. This review gives an overview of oxidative stress in the pathogenesis of corneal diseases.

Published
2018-09-01
How to Cite
Guha, S., Chaurasia, S., & Roy, S. (2018). Oxidative Stress in the Pathogenesis of Corneal Endothelial Dystrophies and Other Corneal Diseases. Reactive Oxygen Species, 6(17), 299–310. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/155
Section
Review Articles