The Antioxidant Activity of Low Doses of Moringa Seeds (Moringa oleifera Lam.) in Hypercholesterolemic Male Rats

  • Haddad A. El Rabey Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia; Genetic Engineering and Biotechnology Institute, Sadat City University, Sadat City, Minufiya, Egypt
  • Jalaluddin A. Khan Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
  • M I. Sakran Department of Biochemistry, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia; Biochemistry Section, Chemistry Department, Faculty of Science, Tanta University, Tanta, Gharbia Governorate, Egypt
  • Maryam A. Al-Ghamdi Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Keywords: Antioxidants; Kidney disease; Lipid peroxidation; Moringa seed

Abstract

The present study evaluated the antioxidant activity of two low doses of moringa seed powder (50 and 100 mg/kg body weight) in hypercholesterolemic male rats. Twenty-four albino rats were divided into four groups. The first group (G1) was the negative control group and was fed fat-rich diet. The second group (G2) was the hypercholesterolemic positive control and was fed 2% cholesterol in the fat-rich diet. The third group (G3) and the fourth group (G4) were also fed 2% cholesterol in the fat-rich diet and co-supplemented with 50 and 100 mg/kg body weight (b.w.) moringa seed powder, respectively, for 8 weeks. The hypercholesterolemic positive control group (G2) showed increase in lipid peroxidation and decrease in antioxidants in the serum and kidney tissue homogenate compared with the negative control group. In addition, the serum urea, uric acid, and creatinine were increased in G2. The histology of the kidney showed some pathological alterations compared with the negative control group. Treating the hypercholesterolemic rats with 50 or 100 mg moringa seeds powder/kg b.w. in G3 and G4, respectively, ameliorated the above altered parameters restoring them nearly to the normal levels, and also restored the normal histology of the kidney. The overall study showed that moringa seed powder has antioxidant activity in hypercholesterolemic male rats.

Published
2018-09-01
How to Cite
El Rabey, H. A., Khan, J. A., Sakran, M. I., & Al-Ghamdi, M. A. (2018). The Antioxidant Activity of Low Doses of Moringa Seeds (Moringa oleifera Lam.) in Hypercholesterolemic Male Rats. Reactive Oxygen Species, 6(17), 363–370. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/154
Section
Original Research Articles