Defining ROS in Biology and Medicine

  • Y. Robert Li Departments of Pharmacology and Pharmaceutical Sciences, Campbell University, Buies Creek, NC 27506, USA; Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA; Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USA; Department of Biology, University of North Carolina, Greensboro, NC 27412, USA
  • Zhenquan Jia Department of Biology, University of North Carolina, Greensboro, NC 27412, USA
  • Michael A. Trush Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA
Keywords: Oxidative stress, Reactive oxygen species, Redox signaling, ROS paradigm

Abstract

Utilization of molecular oxygen by aerobic organisms inevitably results in the formation of a number of oxygen-containing reactive species that are collectively known as reactive oxygen species (ROS). ROS play important roles in both physiology and pathophysiology of aerobic life. The field of ‘ROS biology and medicine’ deals with the involvement of ROS and related species in contemporary biology and medicine. The purpose of this article is to survey common terms and concepts in ROS biology and medicine. It also introduces the ‘ROS paradigm’ so as to provide a conceptual framework for understanding the rapidly evolving field of ROS biology and medicine.

Published
2016-01-01
How to Cite
Li, Y. R., Jia, Z., & Trush, M. A. (2016). Defining ROS in Biology and Medicine. Reactive Oxygen Species, 1(1), 9–21. Retrieved from https://aimsci.com/ros/index.php/ros/article/view/11
Section
Review Articles